Case Studies

Case Studies
4-OXO –N (4- Hydroxyphenyl) Retinamide derivatives as therapeutic agents for the treatment of cancer
Patent relating to a new derivative of vitamin A which combines excellent antitumor efficacy with excellent tolerability

It is a new derivative of vitamin A (sodium 4-oxo-4- HPR) that combines excellent anticancer efficacy with excellent tolerability. Its peculiarity consists in killing cancer cells through two independent mechanisms of action, allowing to effectively […]

Istituto Nazionale Tumori
Case Studies
Bi-specific antibodies to direct cytotoxic T cells to TRAIL-R2 expressing tumors
Patent relating to the construction of a bi-specific antibody structured as scdb

A new bi-specific antibody has been constructed, structured as a “single chain diabody” (scdb) capable of simultaneously recognizing and binding the TRAIL-R2 receptor on the tumor and the CD3 activating molecule on T cells. Unlike […]

Istituto Nazionale Tumori
Case Studies
CAR-T Technology
Patent related to the use of the anti-folate receptor variable antibody part in the creation of CAR

A share of ownership equal to 20% in Patent No. 13/979,927 was recognized to the INT in 2016. The patent, titled “Composing and methods for Treating Cancer” was filed by the University of Pennsylvania on […]

Istituto Nazionale Tumori
Case Studies
Newronika
Spin-off in the field of invasive neuromodulation

Newronika is the first Italian spin-off created by two public entities: Policlinico Hospital and the University of Milan. Newronika operates in the field of neuromodulation, with the development of therapeutic tools and innovative information systems. […]

Policlinico di Milano
Case Studies
SHE-BRAIN
A portable stereotaxic helmet

A research group working at Fondazione Besta with wide expertise in the fields of neuroradiology and neurosurgery, composed by drs. Maria Grazia Bruzzone, Anna Nigri, Maria Luisa Fumagalli, Domenico Aquino, Francesco Prada and Stefania Ferraro […]

Istituto Neurologico Besta
Case Studies
Episkey
Spin-off for the development and marketing of medical devices and reagents derived from blood components obtained from umbilical cord blood

Episkey is an innovative company that develops medical devices and reagents derived from umbilical cord blood focusing in the field of regenerative medicine; Episkey as the licensee of 2 Policlinico’s patents has developed new medical […]

Policlinico di Milano